Publications

2017

  • Younis Baqi, Thanigaimalai Pillaiyar, Aliaa Abdelrahman, Olesja Efa, Samer Alshaibani, Saman Ghasimi, Rhalid Akkari, Kirsten Ritter, Katharina Simon, Andreas Spinrath, Evi Kostenis, Qiang Zhao, Meryem Köse, Vigneshwaran Namasivayam, Christa E. Müller: 3-(-2-Carboxyethyl)indole-2-carboxylic Acid Derivatives: Structural Requirements and Properties of Potent Agonists of the Orphan G Protein–Coupled Receptor GPR17. Journal of Medicinal Chemistry, 2017 (submitted).

  • Marcia Cristina T. dos Santos; Miguel Arturo Barreto-Sanz; Bruna Renata S. Correia; Rosie Bell; Catherine Widnall; Claudia Schulte; Dieter Scheller; Daniela Berg; Walter Maetzler; Pedro A. F. Galante and Andre Nogueira da Costa: miRNA-based Signatures in Cerebrospinal Fluid as Potential Diagnostic Tools for Early Stage Parkinson’s Disease. JAMA Neurology, 2017 (to be submitted).

  • Fabian Heider, Urs Haun, Eva Doering, Mark Kudolo, Catharina Sessler, Wolfgang Albrecht, Stefan Laufer, Pierre Koch: From 2-Alkylsulfanylimidazoles to 2-Alkylimidazoles: An Approach towards Metabolically More Stable p38α MAP Kinase Inhibitors. Molecules 2017, 22, 1729.

  • Daniel Stoessel, Claudia Schulte, Marcia Cristina Teixeira dos Santos, Dieter Scheller, Irene Rebollo-Mesa, Christian Deuschle, Dirk Walther, Nicolas Schauer, Daniela Berg, Andre Nogueira da Costa, Walter Maetzler: Metabolite profiles in plasma and CSF of early clinical Parkinson’s disease. Neurobiology of Aging, 2017 (submitted).

  • David Goldeck, Claudia Schulte, Marcia Cristina Teixeira dos Santos, Dieter Scheller, Walter Maetzler, Lilly Oettinger, Graham Pawelec, Irene Rebollo Mesa, Christian Deuschle, Daniela Berg, Andre Nogueira da Costa: Higher frequencies of T-cells expressing NK-cell markers and chemokine receptor in Parkinson’s disease. Journal of Neuroimmune Pharmacology (submission declined, will be submitted to another jounal not yet defined).

  • Jonathan Vogelgsang, Jens Wiltfang, Hans-W. Klafki: Validation of a chemiluminescence immunoassay for quantifying Amyloid-β in human blood plasma. Edition on Biomarkers for Alzheimer’s Disease Drug Development, to be published in the lab protocol series Methods in Molecular Biology (Series Editor: Prof. John M. Walker), published by Springer (submitted).

  • Aliaa Abdelrahman, Vigneshwaran Development of the first fluorine-18 labelled radioligand for imaging of the adenosine A2B receptor Namasivayam, Sonja Hinz, Anke C. Schiedel, Meryem Köse, Maggie Burton, Ali El‐Tayeb, Michel Gillard, Jürgen Bajorath, Marc de Ryck, and Christa E. Müller: Characterization of P2X4 receptor agonists and antagonists by calcium influx assays, radioligand binding and docking studies. Biochemical Pharmacology, 2017, 125, 41-54.

2016

  • Andreas Brunschweiger, Pierre Koch, Miriam Schlenk, Hamid Radjainia, Felipe Pineda, Michael Wiese, Jörg Hockemeyer, Jag Heer, Frédéric Denonne, and Christa E. Müller: 8-Substituted 1,3 dimethyltetrahydro¬pyrazino[2,1 f]purinediones: water-soluble adenosine receptor antagonists and monoamine oxidase B inhibitors. Bioorganic & Medicinal Chemistry, 2016, 24, 5462-5480.

  • Joachim C. Burbiel, Wadih Ghattas, Petra Küppers, Meryem Köse, Jörg Hockemeyer, Svenja Lacher, Anna-Maria Herzner, Raghuram Rao Akkinepally and Christa E. Müller: 2-Amino [1,2,4]triazolo[1,5-c]quinazolines and derived novel heterocycles – syntheses and structure-activity relationships of potent adenosine receptor antagonists. ChemMedChem 2016, 11, 1 – 16. DOI: 10.1002/cmdc.201600255.

  • Kristina Hoffmann, Meryem Köse, Anke Schiedel, Julia Lisa Hartweg, Marion Schneider, Patrick Foerch, Michel Gillard, Christa E. Müller, Ivar von Kügelgen: Activation of human GPR84 by hydroxy-fatty acids and preparations of bacterial lipopolysaccharides. Biochemical Pharmacology, 2016 (submitted).

  • Isaak Beyer, Nasrollah Rezaei-Ghaleh, Hans Klafki, Jens Wiltfang, Olaf Jahn, Ute Haußmann, Markus Zweckstetter, and Hans-Joachim Knölker: Solid Phase Synthesis and Characteriza-tion of N-Terminally Elongated Aβ−3–x-Peptides. Chemistry – A European Journal 2016, 22, 8685 – 8693, DOI: 10.1002/chem.201600892.

  • Kenneth A. Jacobson, Christa E. Müller: Medicinal Chemistry of Adenosine, P2Y and P2X Receptors. Review article for Neuropharmacology, Special Issue “Purines in Neurodegene-ration and Neuroregeneration”, Neuropharmacology 104 (2016) 31-49.

  • Benedicte Danis, Marijke van Rikxoort, Anita Kretschmann, Jiong Zhang, Patrice Godard, Lidija Andonovic, Franziska Siegel, Daniel Delev, Marec von Lehe, Rafal M. Kaminski, Alexander Pfeifer, Patrik Foerch: Differential expression of miR-184 in temporal lobe epilepsy patients with and without hippocampal sclerosis – Influence on microglial function. Scientific Reports, 2016, 6:33943, DOI: 10.1038/srep33943.

  • Sathish Kumar, Oliver Wirths, Kathrin Stueber, Patrick Wunderlich, Philipp Koch, Sandra Theil, Nasrollah Rezaei-Ghaleh,Markus Zweckstetter, Thomas A. Bayer, Oliver Bruestle, Dietmar R. Thai, Jochen Walter: Phosphorylation of the amyloid β-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity Acta. Neuropathol, DOI 10.1007/s00401-016-1546-0, 22 February 2016.

  • Katharina Simon, Stephanie Hennen, Nicole Merten, Stefanie Blaettermann, Michel Gillard, Evi Kostenis, Jesus Gomeza: The Orphan G Protein-coupled Receptor GPR17 Negatively Regulates Oligodendrocyte Differentiation via Gαi/o and Its Downstream Effector Molecules. Journal of Biological Chemistry, Vol. 291, No. 2, 8 January 2016.

  • Rainer Surges, Anita Kretschmann; Khalid Abnaof; Marijke van Rikxoort; Kirsten Ridder; Holger Fröhlich; Bénédicte Danis; Rafal Kaminski; Patrik Foerch; Christian Elger; Frank Weinsberg; Alexander: Changes in serum miRNAs following generalised convulsive seizures in human mesial temporal lobe epilepsy. Biochemical and Biophysical Research Communications, 2016, 481,13-18.

2015

  • Shweta Bagewadi, Subash Adhikari, Anjani Dhrangadhariya, Afroza Khanam Irin, Christian Ebeling, Aishwarya Alex Namasivayam, Matthew Page, Martin Hofmann-Apitius, Philipp Senger: NeuroTransDB: Highly Curated and Structured Transcriptomic Meta-Data for Neurodegenerative Diseases. Database - The Journal of Biological Databases and Curation, 2015, 1-17.

  • Christa E. Müller: Medicinal chemistry of P2X receptors: allosteric modulators. Current Medicinal Chemistry, 2015, 22, 929-941.

  • Anita Kretschmann, Benedicte Danis, Khalid Abnaof, Lidija Andonovic, Marijke van Rikxoort, Franziska Siegel, Manuela Mazzuferi, Patrice Godard, Etienne Hannon, Rafal Kaminski, Holger Fröhlich, Rafal Kaminski, Patrik Foerch, Alexander Pfeifer: Different microRNA profiles in chronic epilepsy versus acute seizure models. Journal of Molecular Neuroscience, 2015, 55, 466-479.

  • Erfan Younesi, Ashutosh Malhotra, Michaela Gündel, Phil Scordis, Alpha Tom Kodamullil, Matt Page, Bernd Müller, Stephan Springstubbe, Ullrich Wüllner, Dieter Scheller, Martin Hofmann-Apitius: PDON: Parkinson’s disease ontology for representation and modeling of the Parkinson’s disease knowledge domain. Journal of Theoretical Biology and Medical Modelling (2015) 12:20 DOI 10.1186/s12976-015-0017-y, September 2015.

2014

  • Andreas Brunschweiger, Pierre Koch, Miriam Schlenk, Felipe Pineda, Petra Küppers, Sonja Hinz, Meryem Köse, Stefan Ullrich, Jörg Hockemeyer, Michael Wiese, Jag Heer, Christa E. Müller: 8-Benzyltetrahydropyrazino[2,1‑f]purinediones: water-soluble tricyclic xanthine derivatives as multitarget drugs for neurodegenerative diseases. ChemMedChem, 2014, 9, 1704-1724.

  • Meryem Köse, Kirsten Ritter, K. Thiemke, Michel Gillard, Evi Kostenis, Christa E. Müller: Development of [(3)H]2-Carboxy-4,6-dichloro-1H-indole-3-propionic Acid ([(3)H]PSB-12150): A Useful Tool for Studying GPR17. ACS Med Chem Lett., 2014, 5, 326-330.

  • Maoqun Tian, Aliaah Abdelrahman, Stefanie Weinhausen, Sonja Hinz, Stefanie Weyer, Stephan Dosa, Ali El-Tayeb, Christa E. Müller: Carbamazepine derivatives with P2X4 receptor-blocking activity. Bioorg Med Chem 2014, 22, 1077-1088.

  • Younis Baqi, Samer Alshaibani, Kirsten Ritter, Aliaa Abdelrahman, Andreas Spinrath, Evi Kostenis, and Christa E. Müller: Improved synthesis of 4-/6-substituted 2‑carboxy-1H-indole-3-propionic acid derivatives and structure-activity relationships as GPR17 agonists. Medicinal Chemistry Communication, 2014, 5, 86-92.

  • Gereon Poschmann, Katrin Seyfarth, Daniela Besong Agbo, Hans-Wolfgang Klafki, Jan Rozman, Wolfgang Wurst, Jens Wiltfang, Helmut E. Meyer, Martin Klingenspor, Kai Stühler: High-Fat Diet Induced Isoform Changes of the Parkinson's Disease Protein DJ-1. Journal of proteome research, 2014, 13, 2339-2351.

  • Matthias D. Mertens, Sonja Hinz, Christa E. Müller, Michael Gütschow: Alkynyl-coumarinyl ethers as MAO-B inhibitors. Bioorg Med Chem, 2014, 22, 1916-1928.

2013

  • Pierre Koch, Rhalid Akkari, Andreas Brunschweiger, Thomas Borrmann, Miriam Schlenk, Petra Küppers, Meryem Koese, Hamid Radjainia, Joerg Hockemeyer, Katarzyna Kieć-Kononowicz, and Christa E. Müller: 1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases. Bioorganic & Medicinal Chemistry, 2013, 7435–7452.

  • Stephanie Hennen, Lucas Peters, Haibo Wang, Nicole Merten, Andreas Spinrath, Stefanie Blättermann, Rhalid Akkari, Ramona Schrage, Ralf Schröder, Katharina Simon, Daniel Schulz, Celine Vermeiren, Kathrin Zimmermann, Stefan Kehraus, Christel Drewke, Alexander Pfeifer, Gabriele M. König, Klaus Mohr, Michel Gillard, Christa Müller, Q. Richard Lu, Jesus Gomeza, and Evi Kostenis: Decoding signaling and function of the orphan G Protein-coupled receptor GPR17 with a small molecule agonist. Science Signaling, 2013, 6, ra93.

  • D. Besong Agbo, H. Klafki, G. Poschmann, K. Seyfarth, J. Genius, K. Stühler, W. Wurst, H. E. Meyer, M. Klingenspor, and J. Wiltfang: Development of a Capillary Isoelectric Focusing Immunoassay to Measure DJ-1 Isoforms in Biological Samples. Analytical Chemistry, 2013; 443, 197-204.

  • Ute Haußmann, Olaf Jahn, Philipp Linning, Christin Janßen, Thomas Liepold, Erik Portelius, Henrik Zetterberg, Hans-Joachim Knölker, Hans Klafki, Jens Wiltfang: Analysis of Amino-terminal Variants of Amyloid-ß Peptides by Capillary Isoelectric Focusing Immunoassay. Analytical Chemistry, 2013, 85, 8142–8149.

  • Anne Stößel, Miriam Schlenk, Sonja Hinz, Petra Küppers, Jag Heer, Michael Gütschow, Christa E. Müller: Dual Targeting of Adenosine A2A Receptors and Monoamine Oxidase B by 4H-3,1-Benzothiazin-4-Ones. Journal of Medicinal Chemistry, 2013, 56, 4580-4596.

  • Jerome Mertens, Kathrin Stüber, Patrick Wunderlich, Julia Ladewig, Jaideep C. Kesevan, Rik Vandenberghe, Mathieu Vandenbuicke, Philip van Damme, Jochen Walter, Oliver Brüstle, Philipp Koch: APP processing in human pluripotent stem cell-derived neurons is resistant to NSAID-based γ-secretase modulation. Stem Cell Reports, 2013, 1, 491-498.

  • Jerome Mertens, Kathrin Stüber, Daniel Poppe, Jonas Doerr, Julia Ladewig, Oliver Brüstle*, Philipp Koch*: Embryonic stem cell-based modeling of tau pathology in human neurons. Am J Pathol, 2013, 182, 1769-1779.

  • Michael Peitz, Johannes Jungverdorben, Oliver Brüstle: Disease-specific iPS cell models in neuroscience. Current Molecular Medicine, 2013, 13, 832-841.

2012

  • Victor Hernandez-Olmos, Aliaa Abdelrahman, Ali El-Tayeb, Diana Freudendahl, Stephanie Weinhausen, Marc De Ryck, Christa E. Müller: N-Substituted Phenoxazine and Acridone Derivatives: Structure-Activity Relationships of Potent P2X4 Receptor Antagonists. Jounal of Medicinal Chemistry, 2012, 55, 9576-9588.

  • Nikolay T. Tzvetkov, Christa E. Müller: Facile synthesis of 5-amino- and 7-amino-6-azaoxindole derivates. Tetrahedron Letters, 2012, 53, 5597-5601.

  • Nikolay T. Tzvetkov, Harald Euler, Christa E. Müller: Regioselective synthesis of 7,8-dihydroimidazo[5,1-c][1,2,4]triazine-3,6(2H,4H)-dione derivatives – a new drug-like heterocyclic scaffold. Beilstein Journal of Organic Chemistry, 2012, 8, 1584-1593.

  • Philipp Koch, Irfan Y. Tamboli, Jerome Mertens, Patrick Wunderlich, Julia Ladewig, Kathrin Stüber, Hermann Esselmann, Jens Wiltfang, Oliver Brüstle, Jochen Walter: Presenilin-1 L166P Mutant Human Pluripotent Stem Cell-Derived Neurons Exhibit Partial Loss of γ-Secretase Activity in Endogenous Amyloid-β Generation. American Journal of Pathology, 2012, 180, 2404-2416.

  • Christa E. Müller: Purine- and pyrimidine-binding membrane proteins as drug targets. Purinergic Signalling, 2012, 8, 107-175.

  • Wadih Ghattas, Joachim C. Burbiel, Jörg Hockemeyer, Christa E. Müller: [1,2,4]Triazolo[1,5-c]quinazolin-2-amines – potent adenosine A1 and A2A receptor antagonists. Purinergic Signalling, 2012, 8, 107-175.

  • Nikolay T. Tzvetkov, Petra Küppers, Jörg Hockemeyer, Christa E. Müller: N-Amino-substituted xanthine derivatives: affinity at adenosine receptors. Purinergic Signalling, 2012, 8, 107-175.

  • Amelie Zech, Jörg Hockemeyer, Nikolay Tzvetkov, Meryem Köse, Hamid Radjainia, Christa E. Müller: 8-Phenylethynylxanthines – highly potent and selective adenosine A2A receptor antagonists. Purinergic Signalling, 2012, 8, 107-175.

  • Petra Küppers, Amelie Zech, Simone Siebers, Judith Paschkowiak, Jörg Hockemeyer and Christa E. Müller: [3H]PSB-1010 - a new, optimized antagonist radioligand for adenosine A2A receptors. Purinergic Signalling, 2012, 8, 107-175.

  • Dominik Thimm, Miguel Moutinho, Anke C. Schiedel, Christa E. Müller: First Ade for Chinese hamsters - exploring a new adenine receptor. Purinergic Signalling, 2012, 8, 107-175.

  • Melanie Knospe, Anke C. Schiedel, Christa E. Müller: The predicted putative agonist binding site of the rat adenine receptor investigated by mutagenesis studies. Purinergic Signalling, 2012, 8, 107-175.

2011

Peer-Review

  • Christa E. Müller, Kenneth E. Jacobson: Xanthines as Adenosine Receptor antagonists. In B.B. Fredholm (ed.) Handbook of Experimental Pharmacology, Vol. 200, Methylxanthines, 151-199, 2011.

  • Christa E. Müller, Kenneth A. Jacobson: Recent developments in adenosine receptor ligands and their potential as novel drugs. Biochim. Biophys. Acta 2011, 1808, 1290-1308.

  • Bertil B. Fredholm , Adrian P. IJzerman, Kenneth A. Jacobsen, Joel Linden, Christa E. Müller: International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptor - An Update. Pharmacol. Rev., 2011, 63, 1-34.


Non-Peer-Review

  • Christa E. Müller: Q&A with Christa E. Müller, Co-initiator of the Neuroallianz. Interview, NRW Spotlight on Biotechnology, Issue 2, November 2011; 4-5.

2010

Peer-Review

  • Alexander Pfeifer, Holger Lehmann: Pharmacological Potential of RNAi - Focus on miRNA. Pharmacology & Therapeutics, 2010, 126, 217-227.


Non-Peer-Review

  • Christa Müller, Alexander Pfeifer: "Die Neuroallianz – ein neuartiges Konsortium zur Entwicklung innovativer Therapeutika und Diagnostika" in Ernst & Young Biotechnologie-Report 2010 Pharma-Zentrum Bonn.

Facts

To provide the German location of biotechnology and pharma industry with fresh impulsion, the German Federal Ministry for Education and Research (BMBF) started the pharma initiative "BioPharma: The Strategy Competition for Future Medicines". The Neuroallianz Consortium was nominated for this initiative.

The Neuroallianz Consortium has created a novel strategic partnership where various academic institutions and companies are working jointly on innovative diagnostic and therapeutic research projects. The aim is to efficiently transform research into benefits for the patients.

Main focuses are diagnostic and therapy of neurodegenerative diseases such as Parkinson's Disease, or Alzheimer's Dementia, and Epilepsy.

Duration: 2009 – 2018

Budget: 40 Mio. €

Logo BMBF